AIMBE
In a significant breakthrough in cancer research, scientists from the Texas A&M University Health Science Center (Texas A&M Health) have uncovered a previously unknown mechanism that fuels the growth of a rare and aggressive form of kidney cancer, known as translocation renal cell carcinoma (tRCC). This discovery, detailed in a recent study published in Nature Communications, highlights how tiny molecular “hubs” within cancer cells utilize RNA in a manner that accelerates disease progression, presenting new avenues for potential treatments.
Translocation renal cell carcinoma, primarily affecting children and young adults, currently lacks effective therapeutic options, making this research particularly crucial. The cancer arises from abnormal hybrid genes called TFE3 oncofusions, which occur due to chromosomal errors. Until now, the precisely aggressive nature of tRCC and the role of these fusion proteins had eluded researchers… Continue reading.
